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Article

Transcriptional activation by bidirectional RNA polymerase II elongation over a silent promoter.

EMBO reports - 1 Oct 2005

Leupin Olivier, Attanasio Catia, Marguerat Samuel, Tapernoux Myriam, Antonarakis Stylianos E, Conrad Bernard

Abstract excerpt

Transcriptional interference denotes negative cis effects between promoters. Here, we show that promoters can also interact positively. Bidirectional RNA polymerase II (Pol II) elongation over the silent human endogenous retrovirus (HERV)-K 18 promoter (representative of 2.5 x 10(3) similar promoters genomewide) activates transcription. In tandem constructs, an upstream promoter activates HERV-K 18 transcription....

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Identifiers

PMID: 16113646
DOI: 10.1038/sj.embor.7400502
PMCID: PMC1369183

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