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Longitudinal modeling of human neuronal aging identifies RCAN1-TFEB pathway contributing to neurodegeneration of Huntington’s disease

2023-05-09

Abstract excerpt

<title>Abstract</title> <p>Aging is a common risk factor in neurodegenerative disorders and the ability to investigate aging of neurons in an isogenic background would facilitate discovering the interplay between neuronal aging and onset of neurodegeneration. Here, we perform direct neuronal reprogramming of longitudinally collected human fibroblasts to reveal genetic pathways altered at different ages. Comparati...

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Literature Corpus work
b2b21b14-ae64-5758-bf33-6bd31e26f882
DOI
10.21203/rs.3.rs-2815300/v1
Open publication

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Longitudinal modeling of human neuronal aging identifies RCAN1-TFEB pathway contributing to neurodegeneration of Huntington’s diseaseDOI 10.21203/rs.3.rs-2815300/v1
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