Article

An accelerated human in-vitro aging model mimics in-vivo aging and facilitates dynamic testing of anti-aging compounds

2025-03-28

Abstract excerpt

<title>Abstract</title> <p> Biological aging drives cellular dysfunction and human disease, yet studying human-specific aging dynamics remains challenging due to limited experimental platforms. Here we show that long-term post-mitotic culture of human fibroblasts authentically recapitulates and accelerates in-vivo aging signatures. Longitudinal paired transcriptomic-epigenetic analyses revealed that in-vitro agi...

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Literature Corpus work: c04adc85-1e76-5e81-bd0d-874c20df36ad
DOI: 10.21203/rs.3.rs-6173768/v1

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