Article

Temporal single-cell atlas of full-length Huntington’s disease mouse model defines stage-specific signatures of corticostriatal dysfunction

2026-01-08

Abstract excerpt

<h4>ABSTRACT</h4> Huntington’s disease involves progressive corticostriatal dysfunction; however, the timing of region-specific transcriptional changes remains unresolved at cellular resolution. Here, we provide a temporal single-nucleus transcriptomic atlas of striatum and motor cortex from zQ175 knock-in mice at 6 and 18 months. This full-length Huntingtin model enables staging of progressive circuit dysfunctio...

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Literature Corpus work: a8a06c13-74a4-5f08-9185-d30f9079095c
DOI: 10.64898/2026.01.07.698249

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