Article

Age-dependent alterations in the human striatum identify a PPP1R15B-miR-196a node as a modifier of Huntington’s disease phenotypes

2024-04-10

Abstract excerpt

<title>Abstract</title> <p>Polyglutamine expansion in Huntingtin (HTT) causes its aggregation and progressive loss of striatal neurons in Huntington’s disease (HD). HD is a mostly adult-onset neurodegenerative disorder with no disease-modifying therapies. Here we found that human striatal aging is associated with a global upregulation of genes involved in translation, including the translation and proteostasis re...

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Literature Corpus work: 0e65aafc-5a52-5bd8-989e-806fff3981ab
DOI: 10.21203/rs.3.rs-4104643/v1

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