Article

A linear regression model predicts human brain ageing and reveals differential neuronal biological ageing relevant for Parkinson’s disease susceptibility

2025-12-02

Abstract excerpt

<h4>Summary</h4> Biological brain ageing is a major risk factor for neurodegenerative diseases, which are characterized by selective degeneration of particular neuron types. We analyzed the impact of ageing on the transcriptome of neurons in the ventral tegmental area (VTA), substantia nigra pars compacta (SNc) and locus coeruleus (LC), that show differential vulnerabilities to Parkinson’s disease. Neurons were i...

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Literature Corpus work: 81e71ec5-cb96-5e90-a0c6-4d437940e4c5
DOI: 10.64898/2025.12.01.691179

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