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Article

Targeting CDC42 with CASIN Reprograms Cell Type Specific Transcriptomes and MAPK Driven Transcription Factor Networks in the Aging Brain

2026-08-13

Abstract excerpt

<h4>Background: </h4> Parkinson disease (PD) is driven by alpha synuclein (alpha syn) aggregation and affects vulnerable dopaminergic and GABAergic neurons, and its incidence rises dramatically with age. In our alpha syn mouse model, motor impairment required both alpha syn oligomers and the aging milieu, and pharmacological inhibition of the age hyperactivated Rho GTPase CDC42 with CASIN fully restored motor func...

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Literature Corpus work
61cc8703-d6b7-544b-8d89-6b6c18331882
DOI
10.64898/2026.08.07.742974
Open publication

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Targeting CDC42 with CASIN Reprograms Cell Type Specific Transcriptomes and MAPK Driven Transcription Factor Networks in the Aging BrainDOI 10.64898/2026.08.07.742974
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