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Modeling Huntington’s disease against age-related genes reveals <i>CXXC4</i> as an epigenetic target to restore DRD1 striatal neuron activity

2025-12-15

Abstract excerpt

<h4>ABSTRACT</h4> Neurons adapt gene expression to counter aging, yet the mechanisms by which they harness age- related genes to resist neurodegenerative disease remain elusive. We found that transcriptionalaging inversion (TAGI) in the Drd1 -expressing striatal neurons ( Drd1 SNs) of Huntington’s disease (HD) knock-in ( Hdh ) mice exhibits discrete patterns against a TAG-like (TAGL) signature. Strikingly, TAG...

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Literature Corpus work
b1b80a6d-689b-5f55-b547-8c19eba19b08
DOI
10.64898/2025.12.12.693965
Open publication

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Modeling Huntington’s disease against age-related genes reveals <i>CXXC4</i> as an epigenetic target to restore DRD1 striatal neuron activityDOI 10.64898/2025.12.12.693965
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