Article

A deep-learning-based screening platform in aging-relevant human motor neurons to identify therapeutic compounds for amyotrophic lateral sclerosis

2023-11-22

Abstract excerpt

Age is the primary risk factor for most neurodegenerative diseases including amyo-trophic lateral sclerosis (ALS). Despite the clear importance of age on the development and progression of ALS, age is rarely considered a factor in cellular or animal models of ALS. The recent advent of direct reprogramming methodologies, whereby somatic cells such as fibroblasts can be converted into neurons while retaining the age...

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Literature Corpus work: f6746ac4-c4ce-575c-8ff8-b55c89f240ac
DOI: 10.1101/2023.11.21.568079

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