Article
Extrachromosomal DNA is associated with decreased immune cell infiltration and antigen presentation, represents a potential cancer immune evasion mechanism
2022-02-06
Abstract excerpt
Extrachromosomal DNA (ecDNA) is a type of circular and tumor specific genetic element. EcDNA has been reported to display open chromatin structure, facilitate oncogene amplification and genetic material unequal segregation, and is associated with poor cancer patients’ prognosis. The ability of immune evasion is a typical feature for cancer progression, however the tumor intrinsic factors that determine immune evas...
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Identifiers and source
- Literature Corpus work
- b2afe40f-f041-5760-99d1-e1d19c77e171
- DOI
- 10.1101/2022.02.04.479205