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Article

Current understanding of extrachromosomal circular DNA in cancer pathogenesis and therapeutic resistance.

Journal of hematology & oncology - 14 Sept 2020

Yan Yuanliang, Guo Guijie, Huang Jinzhou, Gao Ming, Zhu Qian, Zeng Shuangshuang, Gong Zhicheng, Xu Zhijie

Abstract excerpt

Extrachromosomal circular DNA was recently found to be particularly abundant in multiple human cancer cells, although its frequency varies among different tumor types. Elevated levels of extrachromosomal circular DNA have been considered an effective biomarker of cancer pathogenesis. Multiple reports have demonstrated that the amplification of oncogenes and therapeutic resistance genes located on extrachromosomal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32928268
DOI: 10.1186/s13045-020-00960-9
PMCID: PMC7491193

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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