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Clinicopathological and genomic features of extrachromosomal DNA in gastric cancer.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Jan 2026

Hokazono Yukio, Saito-Adachi Mihoko, Hama Natsuko, Totoki Yasushi, Nakamura Hiromi, Arai Yasuhito, Yachida Shinichi, Fukagawa Akihiko, Rokutan Hirofumi, Ushiku Tetsuo, Shibata Tatsuhiro

Abstract excerpt

BACKGROUND: Extrachromosomal DNA (ecDNA), a form of circular DNA located outside chromosomes, is a common driver of oncogene amplification. Recent pan-cancer studies have associated ecDNA with cancer progression and poor prognosis. Moreover, its relationship with specific genomic features is becoming increasingly evident. However, the clinicopathological characteristics and underlying genomic mechanisms of ecDNA...

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PMID: 41107687
DOI: 10.1007/s10120-025-01666-y

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TP53

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