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Extrachromosomal DNA formation enables tumor immune escape potentially through regulating antigen presentation gene expression

4 Mar 2022

Abstract excerpt

Extrachromosomal DNA (ecDNA) is a type of circular and tumor specific genetic element. EcDNA has been reported to display open chromatin structure, facilitate oncogene amplification and genetic material unequal segregation, and is associated with poor cancer patients' prognosis. The ability of immune evasion is a typical feature for cancer progression, however the tumor intrinsic factors that determine immune...

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PMID: 35246593
DOI: 10.1038/s41598-022-07530-8

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