Article
Extrachromosomal circular DNA in colorectal cancer: biogenesis, function and potential as therapeutic target
1 Mar 2023
Abstract excerpt
Extrachromosomal circular DNA (ecDNA) has gained renewed interest since its discovery more than half a century ago, emerging as critical driver of tumor evolution. ecDNA is highly prevalent in many types of cancers, including colorectal cancer (CRC), which is one of the most deadly cancers worldwide. ecDNAs play an essential role in regulating oncogene expression, intratumor heterogeneity, and resistance to...
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