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Extrachromosomal Circular DNAs: An Extra Piece of Evidence to Depict Tumor Heterogeneity

31 May 2019

Abstract excerpt

The tumor microenvironment (TME) comprises a heterogeneous number and type of cellular and noncellular components that vary in the context of molecular, genomic and epigenomic levels. The genotypic diversity and plasticity within cancer cells are known to be affected by genomic instability and genome alterations. Besides genomic instability within the chromosomal linear DNA, an extra factor appears in the form of...

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PMID: 31285839
DOI: 10.2144/fsoa-2019-0024

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