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Synaptic dysfunction and dysregulation of extracellular matrix-related genes in dopaminergic neurons derived from Parkinson’s disease sporadic patients and with <i>GBA1</i> mutations

2023-04-11

Abstract excerpt

Parkinson’s disease (PD) is a neurodegenerative disease with both genetic and sporadic origins. In this study, we investigated the electrophysiological properties, synaptic activity, and gene expression differences in dopaminergic (DA) neurons derived from induced pluripotent stem cells (iPSCs) of healthy controls, sporadic PD (sPD) patients, and PD patients with GBA1 mutations. Our results demonstrate reduced sod...

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Identifiers and source

Literature Corpus work
b28afa1d-0953-5acd-905d-0ce2c9f8c0f1
DOI
10.1101/2023.04.10.536143
Open publication

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