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Diverging Parkinson’s Disease Pathology between patient-derived <i> GBA <sup>N370S</sup> , LRRK2 <sup>G2019S</sup> </i> and engineered <i> SNCA <sup>A53T</sup> </i> iPSC-derived Dopaminergic Neurons

2023-01-07

Abstract excerpt

Multiple neurodegenerative disorders, including Parkinson’s disease (PD) and Alzheimer’s disease-associated dementia (ADAD), are linked with dopaminergic (DA) neuron death and a resulting reduction in dopamine levels in the brain. DA neuron degeneration and the risk of developing PD is connected to genetic mutations affiliated with lysosomal function and protein degradation. Accessible human cellular models for PD...

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Literature Corpus work
89ee3f71-616c-5acd-9324-91714b093eab
DOI
10.1101/2023.01.06.521264
Open publication

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Diverging Parkinson’s Disease Pathology between patient-derived <i> GBA <sup>N370S</sup> , LRRK2 <sup>G2019S</sup> </i> and engineered <i> SNCA <sup>A53T</sup> </i> iPSC-derived Dopaminergic NeuronsDOI 10.1101/2023.01.06.521264
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