Article

<i>GBA1</i> deficiency differentially affects endolysosomal trafficking in neurons versus astrocytes

2026-01-13

Abstract excerpt

Mutations in the gene glucosidase, beta acid 1 (GBA1) are the strongest genetic risk factor for Parkinson’s disease (PD) and are associated with faster disease progression. GBA1 is expressed in all cell types of the central nervous system, with some evidence supporting higher expression in glial cells than neurons. To elucidate possible specific functions in neurons versus glia, we differentiated human induced p...

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Literature Corpus work: 2c466474-bf07-5b1b-9659-f0f523395b05
DOI: 10.64898/2026.01.12.697563

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