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Upregulated extracellular matrix-related genes and impaired synaptic activity in dopaminergic and hippocampal neurons derived from Parkinson’s disease patients with <i>PINK1</i> and <i>PARK2</i> mutations

2022-12-11

Abstract excerpt

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. Primary symptoms of PD arise with the loss of dopaminergic (DA) neurons in the Substantia Nigra Pars Compacta, but it affects the hippocampus and cortex also, usually in its later stage. Approximately 15% of PD cases familial with a genetic mutation. Two of the most associated genes with autosomal recessive (AR) early-onset familial P...

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Literature Corpus work
e9086773-b523-5f93-853e-97a07a1cbfe3
DOI
10.1101/2022.12.09.519781
Open publication

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Upregulated extracellular matrix-related genes and impaired synaptic activity in dopaminergic and hippocampal neurons derived from Parkinson’s disease patients with <i>PINK1</i> and <i>PARK2</i> mutationsDOI 10.1101/2022.12.09.519781
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