Article

<i>GBA1</i> mutations alter neuronal firing and structure, regulating VGLUT2 and CRYAB in dopamine neurons

2024-08-07

Abstract excerpt

Mutations in the GBA1 gene are major risk factors for Parkinsońs disease (PD), but their role in PD pathology is not fully understood. The impact of GBA1 mutations was investigated in dopamine (DA) neurons obtained from induced pluripotent stem cells (iPSCs) derived from PD patients carrying the N370S or L444P GBA1 mutation. DA neurons co-expressing TH and VGLUT2 were detected in the cultures, and their number...

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Literature Corpus work: 0a1ce5bb-f73f-55c6-bce0-6d66db0178cf
DOI: 10.1101/2024.08.05.606574

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