Article

Rare variants alter mitochondrial lipid homeostasis and neuronal excitability in PD patient-derived dopaminergic neurons

2026-04-10

Abstract excerpt

Parkinson’s disease (PD) exhibits substantial genetic heterogeneity, yet how combinations of rare variants converge on disease-relevant cellular mechanisms remains unclear. Here, we generated human induced pluripotent stem cell-derived dopaminergic neurons from PD patients carrying rare variants in recently implicated genes and performed integrated electrophysiological, proteomic, lipidomic, and genetic analyses....

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Literature Corpus work: 7a920d7b-33b2-548d-91a7-2ec4c4856136
DOI: 10.64898/2026.04.10.717646

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