Article

Parallel Neurodegenerative Phenotypes in Sporadic Parkinson’s Disease Fibroblasts and Midbrain Dopamine Neurons

2023-02-12

Abstract excerpt

<h4>ABSTRACT</h4> Understanding the mechanisms causing Parkinson’s disease (PD) is vital to the development of much needed early diagnostics and therapeutics for this debilitating condition. Here, we report cellular and molecular alterations in skin fibroblasts of late-onset sporadic PD subjects, that were recapitulated in matched induced pluripotent stem cell (iPSC)-derived midbrain dopamine (DA) neurons, reprog...

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Literature Corpus work: ac3c6d56-3c9b-5625-8905-828f3846cd1a
DOI: 10.1101/2023.02.10.527867

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