Article
Quantitative proteomic analysis of the hippocampus in the 5XFAD mouse model at early stages of Alzheimer's disease pathology.
Journal of Alzheimer's disease : JAD - 1 Jan 2013
Hong Ingie, Kang Taewook, Yoo Yongcheol, Park Royun, Lee Junuk, Lee Sukwon, Kim Jeongyeon, Song Boemjong, Kim Se-Young, Moon Minho, Yun Ki Na, Kim Jin Young, Mook-Jung Inhee, Park Young Mok, Choi Sukwoo
Abstract excerpt
Alzheimer's disease (AD) is characterized by progressive memory loss accompanied by synaptic and neuronal degeneration. Although research has shown that substantial neurodegeneration occurs even during the early stages of AD, the detailed mechanisms of AD pathogenesis are largely unknown because of difficulties in diagnosis and limitations of the analytical methods. The 5XFAD mouse model harbors five early-onset...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.