Human-mouse proteomics reveals the shared pathways in Alzheimer's disease and delayed protein turnover in the amyloidome

Abstract excerpt

<title>Abstract</title> <p>Murine models of Alzheimer’s disease (AD) are crucial for elucidating disease mechanisms but have limitations in fully representing AD molecular complexities. We comprehensively profiled age-dependent brain proteome and phosphoproteome (n > 10,000 for both) across multiple mouse models of amyloidosis. We identified shared pathways by integrating with human metadata, and prioritized nove...

Topics

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• Alzheimer's disease research and treatments
• Amyloid beta-Protein Precursor
• Amyloid Precursor Protein Secretases
• Bioinformatics and Genomic Networks
• Cholinesterase and Neurodegenerative Diseases
• Endoplasmic Reticulum Stress and Disease
• Hippocampus
• Presenilin-1

Identifiers and source

Literature Corpus work

dad89f10-14b5-500b-9f82-e20b4d55128c

DOI

10.21203/rs.3.rs-5194931/v1