Article
A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer’s disease
2023-01-18
Abstract excerpt
<h4>Background</h4> Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β (Aβ) peptides in intra- and extracellular deposits. How Aβ aggregates perturb the proteome in brains of patients and AD transgenic mouse models, however, remains largely unclear. State-of-the-art mass spectrometry (MS) methods can comprehensively detect proteomic alterations in neurodegenerative disorders, providing rel...
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Identifiers and source
- Literature Corpus work
- f3493768-aeb7-5cac-bb40-c9a494b38bd7
- DOI
- 10.1101/2023.01.16.523715