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Article

Molecular and functional signatures in a novel Alzheimer's disease mouse model assessed by quantitative proteomics.

Molecular neurodegeneration - 16 Jan 2018

Kim Dong Kyu, Park Joonho, Han Dohyun, Yang Jinhee, Kim Ahbin, Woo Jongmin, Kim Youngsoo, Mook-Jung Inhee

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD), the most common neurodegenerative disorder, is characterized by the deposition of extracellular amyloid plaques and intracellular neurofibrillary tangles. To understand the pathological mechanisms underlying AD, developing animal models that completely encompass the main features of AD pathologies is indispensable. Although mouse models that display pathological hallmarks of...

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PMID: 29338754
DOI: 10.1186/s13024-017-0234-4
PMCID: PMC5771139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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