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Blocking Immune Checkpoint—LAIR1: Disrupting the LAIR1—FXIII-A—Collagen Immunosuppressive Circuit for Enhanced Antitumor Therapeutics

2024-04-10

Abstract excerpt

<title>Abstract</title> <p>Recent evidence suggests that tumor-associated myeloid cells (TAMCs), which include tumor-associated macrophages (TAM) and myeloid-derived suppressor cells (MDSC), play a significant role in cancer immunosuppression and progression. These cells constitute up to 50% of a tumor's total mass and play pivotal roles in dampening the immune response, thereby negatively affecting patient survi...

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Literature Corpus work: ddd03e89-c452-587f-9f26-c7af4a373de1
DOI: 10.21203/rs.3.rs-4189094/v1

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