Article

Pan-cancer transcriptomic analysis of CNS tumor stroma identifies a population of perivascular fibroblasts that predict poor immunotherapy response in glioblastoma patients

2023-05-15

Abstract excerpt

<title>Abstract</title> <p>Excessive deposition of extracellular matrix (ECM) is a hallmark of solid tumors; however, it remains poorly understood which cellular and molecular components contribute to the formation of ECM stroma in central nervous system (CNS) tumors. Here, we undertook a pan-CNS analysis of retrospective gene expression datasets to characterize inter- and intra-tumoral heterogeneity of ECM remod...

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Literature Corpus work: 0b3306b1-77cf-57d1-b5d9-a9da561f1598
DOI: 10.21203/rs.3.rs-2931886/v1

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