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Cancer-associated fibroblast–secreted collagen is associated with immune inhibitor receptor LAIR1 in gliomas

14 Feb 2024

Abstract excerpt

A recently published JCI paper revealed that cancer-associated fibroblasts (CAFs) are present in glioblastoma and are defined by the presence of 9 transcriptional markers (1).CAFs can form a barrier around cancer cells that prevents their detection by T cells (2).The normal brain has low levels of collagen, but deposition increases in gliomas, especially around vessels.In addition to collagen facilitating tumor...

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PMID: 38357919
DOI: 10.1172/jci176613

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