Back to search

Article

Distinct Tumor-TAM Interactions in IDH-Stratified Glioma Microenvironments unveiled by Single-Cell and Spatial Transcriptomics

2024-05-27

Abstract excerpt

<h4>ABSTRACT</h4> Tumor-associated macrophages (TAMs) residing in the tumor microenvironment (TME) are characterized by their pivotal roles in tumor progression, antitumor immunity, and TME remodeling. However, a thorough comparative characterization of tumor-TAM crosstalk across IDH-defined categories of glioma remains elusive. We delineated the phenotypic heterogeneity of TAMs across IDH-stratified gliomas. Not...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f2025cbb-485d-5756-8c16-00008575f4bd
DOI
10.1101/2024.05.23.595505
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Distinct Tumor-TAM Interactions in IDH-Stratified Glioma Microenvironments unveiled by Single-Cell and Spatial TranscriptomicsDOI 10.1101/2024.05.23.595505
Distinct tumor-TAM interactions in IDH-stratified glioma microenvironments unveiled by single-cell and spatial transcriptomicsSemantic proximity
Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights tumor-promoting macrophage cells in GlioblastomaSemantic proximity
Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights stumor-promoting macrophage cells in GlioblastomaSemantic proximity
Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights stumor-promoting macrophage cells in GlioblastomaSemantic proximity
Mapping the spatial architecture of glioblastoma from core to edge delineates niche-specific tumor cell states and intercellular interactionsSemantic proximity
Revealing the role of SPP1+ macrophages in glioma prognosis and therapeutic targeting by investigating tumor-associated macrophage landscape in grade 2 and 3 gliomasSemantic proximity
Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma.Semantic proximity
Single-Cell Transcriptomics Reveals the Heterogeneity of the Immune Landscape of IDH-Wild-Type High-Grade Gliomas.Semantic proximity
Immune cell gene expression signatures in diffuse glioma are associated with IDH mutation status, patient outcome and malignant cell state, and highlight the importance of specific cell subsets in glioma biology.Semantic proximity
Single-Cell Transcriptomics of Glioblastoma Reveals a Unique Tumor Microenvironment and Potential Immunotherapeutic Target Against Tumor-Associated MacrophageSemantic proximity
New insights into the Immune TME of adult-type diffuse gliomas.Semantic proximity
Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.Semantic proximity
Select a neighboring publication to make it the new centre.