Article

Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes

2020-03-29

Abstract excerpt

One life-threatening outcome of cardiovascular disease is myocardial infarction, where cardiomyocytes are deprived of oxygen. To study inter-individual differences in response to hypoxia, we established an in vitro model of induced pluripotent stem cell-derived cardiomyocytes from 15 individuals. We measured gene expression levels, chromatin accessibility, and methylation levels in four culturing conditions that...

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Literature Corpus work: b225232b-ea3f-5bfe-b7b8-e3026f259e76
DOI: 10.1101/2020.03.28.012823

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