Article

Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions

2021-01-31

Abstract excerpt

Genetic effects on gene expression and splicing can be modulated by cellular and environmental factors; yet interactions between genotypes, cell type and treatment have not been comprehensively studied together. We used an induced pluripotent stem cell system to study multiple cell types derived from the same individuals and exposed them to a large panel of treatments. Cellular responses involved different genes a...

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Literature Corpus work: c595d73f-0f18-53d5-9210-fd24d3691eb7
DOI: 10.1101/2021.01.29.428868

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