Article

Oxygen-induced stress reveals context-specific gene regulatory effects in human brain organoids

2024-09-03

Abstract excerpt

The interaction between genetic variants and environmental stressors is key to understanding the mechanisms underlying neurological diseases. In this study, we used human brain organoids to explore how varying oxygen levels expose context-dependent gene regulatory effects. By subjecting a genetically diverse panel of 21 brain organoids to hypoxic and hyperoxic conditions, we identified thousands of gene regulatory...

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Literature Corpus work: 8692c8a9-1f77-5029-b13a-d30b90d9cca1
DOI: 10.1101/2024.09.03.611030

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