Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes.

eLife - 8 Feb 2021

Ward Michelle C, Banovich Nicholas E, Sarkar Abhishek, Stephens Matthew, Gilad Yoav

Abstract excerpt

One life-threatening outcome of cardiovascular disease is myocardial infarction, where cardiomyocytes are deprived of oxygen. To study inter-individual differences in response to hypoxia, we established an in vitro model of induced pluripotent stem cell-derived cardiomyocytes from 15 individuals. We measured gene expression levels, chromatin accessibility, and methylation levels in four culturing conditions that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia

Share to Myocardial Infarction

Share to Myocytes, Cardiac

Share to Oxygen

Share to Quantitative Trait Loci

Share to Stress, Physiological

Source

Open in PubMed Open full text

Identifiers

PMID: 33554857
DOI: 10.7554/eLife.57345
PMCID: PMC7906610

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes.PMID 33554857Read ↗

Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytesSemantic proximity Read ↗

Inter-species differences in response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzeesSemantic proximity Read ↗

Single cell multiomics and 3D genome architecture reveal novel pathways of human heart failureSemantic proximity Read ↗

Single-Cell Sequencing Reveals Lineage-Specific Dynamic Genetic Regulation of Gene Expression During Human Cardiomyocyte DifferentiationSemantic proximity Read ↗

A gene regulatory element modulates myosin expression and controls cardiomyocyte response to stressSemantic proximity Read ↗

Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditionsSemantic proximity Read ↗

Metabolic disease-relevant stimuli unmask context-dependent genetic regulation of cardiometabolic loci in human adipocytesSemantic proximity Read ↗

scMEGA: Single-cell Multiomic Enhancer-based Gene Regulatory Network InferenceSemantic proximity Read ↗

Disease-associated loci share properties with response eQTLs under common environmental exposuresSemantic proximity Read ↗

Oxygen-induced stress reveals context-specific gene regulatory effects in human brain organoidsSemantic proximity Read ↗

Disease-associated loci share properties with response eQTLs under common environmental exposuresSemantic proximity Read ↗

Epigenomes: the missing heritability in human cardiovascular disease?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.