Article

iPSC culture expansion selects against putatively actionable mutations in the mitochondrial genome

2020-11-05

Abstract excerpt

While human induced pluripotent stem cells (iPSCs) offer fascinating prospects for research and clinics, evaluating their genomic stability before applications is of utmost importance. During reprogramming, clonal hiPSC lines derived from the same parental cell population were observed to harbor different mitochondrial DNA (mtDNA) variants and variant heteroplasmy levels. It is unknown to date to which extent this...

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Literature Corpus work: b22166bf-7df3-5a7c-bcec-d1c9c1db98de
DOI: 10.1101/2020.11.05.369694

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