Article
Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell-like metabolic reprogramming.
Stem cells (Dayton, Ohio) - 1 Sept 2011
Prigione Alessandro, Lichtner Björn, Kuhl Heiner, Struys Eduard A, Wamelink Mirjam, Lehrach Hans, Ralser Markus, Timmermann Bernd, Adjaye James
Abstract excerpt
Human induced pluripotent stem cells (iPSCs) have been recently found to harbor genomic alterations. However, the integrity of mitochondrial DNA (mtDNA) within reprogrammed cells has yet to be investigated. mtDNA mutations occur at a high rate and contribute to the pathology of a number of human disorders. Furthermore, the lack of mtDNA integrity may alter cellular bioenergetics and limit efficient...
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