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Article

Increased mitochondrial mutation heteroplasmy induces aging phenotypes in pluripotent stem cells and their differentiated progeny.

Aging cell - 1 Mar 2025

Vandiver Amy R, Torres Alejandro, Sanden Amberly, Nguyen Thang L, Gasilla Jasmine, Doan Mary T, Martirosian Vahan, Hoang Austin, Wanagat Jonathan, Teitell Michael A

Abstract excerpt

The mitochondrial genome (mtDNA) is an important source of inherited extranuclear variation. Clonal increases in mtDNA mutation heteroplasmy have been implicated in aging and disease, although the impact of this shift on cell function is challenging to assess. Reprogramming to pluripotency affects mtDNA mutation heteroplasmy. We reprogrammed three human fibroblast lines with known heteroplasmy for deleterious...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39680477
DOI: 10.1111/acel.14402
PMCID: PMC11896400

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