Article
The relevance of mitochondrial DNA variants fluctuation during reprogramming and neuronal differentiation of human iPSCs.
Stem cell reports - 10 Aug 2021
Palombo Flavia, Peron Camille, Caporali Leonardo, Iannielli Angelo, Maresca Alessandra, Di Meo Ivano, Fiorini Claudio, Segnali Alice, Sciacca Francesca L, Rizzo Ambra, Levi Sonia, Suomalainen Anu, Prigione Alessandro, Broccoli Vania, Carelli Valerio, Tiranti Valeria
Abstract excerpt
The generation of inducible pluripotent stem cells (iPSCs) is a revolutionary technique allowing production of pluripotent patient-specific cell lines used for disease modeling, drug screening, and cell therapy. Integrity of nuclear DNA (nDNA) is mandatory to allow iPSCs utilization, while quality control of mitochondrial DNA (mtDNA) is rarely included in the iPSCs validation process. In this study, we performed...
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