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Article

Natural underlying mtDNA heteroplasmy as a potential source of intra-person hiPSC variability.

The EMBO journal - 15 Sept 2016

Perales-Clemente Ester, Cook Alexandra N, Evans Jared M, Roellinger Samantha, Secreto Frank, Emmanuele Valentina, Oglesbee Devin, Mootha Vamsi K, Hirano Michio, Schon Eric A, Terzic Andre, Nelson Timothy J

Abstract excerpt

Functional variability among human clones of induced pluripotent stem cells (hiPSCs) remains a limitation in assembling high-quality biorepositories. Beyond inter-person variability, the root cause of intra-person variability remains unknown. Mitochondria guide the required transition from oxidative to glycolytic metabolism in nuclear reprogramming. Moreover, mitochondria have their own genome (mitochondrial DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27436875
DOI: 10.15252/embj.201694892
PMCID: PMC5282833

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