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Article

Cell reprogramming shapes the mitochondrial DNA landscape.

Nature communications - 2 Sept 2021

Wei Wei, Gaffney Daniel J, Chinnery Patrick F

Abstract excerpt

Individual induced pluripotent stem cells (iPSCs) show considerable phenotypic heterogeneity, but the reasons for this are not fully understood. Comprehensively analysing the mitochondrial genome (mtDNA) in 146 iPSC and fibroblast lines from 151 donors, we show that most age-related fibroblast mtDNA mutations are lost during reprogramming. However, iPSC-specific mutations are seen in 76.6% (108/141) of iPSC lines...

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Share to Cellular Reprogramming
Share to Cellular Senescence
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblasts

Share to Gene Expression

Share to Genome, Mitochondrial

Share to Heteroplasmy

Share to Induced Pluripotent Stem Cells

Source

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Identifiers

PMID: 34475388
DOI: 10.1038/s41467-021-25482-x
PMCID: PMC8413449

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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