Shifting the Balance: Mitochondrial Heteroplasmy as a Driver of Cardiac Disease.

Abstract excerpt

Mitochondrial heteroplasmy represents a fundamental determinant of mitochondrial function and disease, yet its consequences vary across different tissues. Although mitotic tissues possess mechanisms, such as cell division and mitochondrial turnover, to dilute or remove deleterious variants, postmitotic tissues lack this renewal capacity and are disproportionately vulnerable. Neuromuscular and neurodegenerative...

Topics

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• DNA, Mitochondrial
• Heart Diseases
• Heteroplasmy
• Mitochondria, Heart
• Mutation