Article
Induced pluripotent stem cells (iPSCs) for modeling mitochondrial DNA disorders.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2015
Prigione Alessandro
Abstract excerpt
Defects in mitochondrial DNA (mtDNA) are a frequent cause of genetic disease, with a minimum prevalence of 1 in 5,000 individuals. These disorders often present with neurological features, exhibit high clinical variability, and lack effective treatments. Viable disease models would be critical to elucidate the genotype/phenotype relationship and improve disease management. However, the peculiarities of...
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