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Article

iPSC culture expansion selects against putatively actionable mutations in the mitochondrial genome.

Stem cell reports - 12 Oct 2021

Kosanke Maike, Davenport Colin, Szepes Monika, Wiehlmann Lutz, Kohrn Tim, Dorda Marie, Gruber Jonas, Menge Kaja, Sievert Maike, Melchert Anna, Gruh Ina, Göhring Gudrun, Martin Ulrich

Abstract excerpt

Therapeutic application of induced pluripotent stem cell (iPSC) derivatives requires comprehensive assessment of the integrity of their nuclear and mitochondrial DNA (mtDNA) to exclude oncogenic potential and functional deficits. It is unknown, to which extent mtDNA variants originate from their parental cells or from de novo mutagenesis, and whether dynamics in heteroplasmy levels are caused by inter- and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34560000
DOI: 10.1016/j.stemcr.2021.08.016
PMCID: PMC8514965

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