Article

GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme

2021-04-09

Abstract excerpt

<h4>SUMMARY</h4> To achieve precise cellular regulation, E3 ubiquitin ligases must be configured to match substrate quaternary structures. Here, by studying the yeast GID complex, mutation of which is G lucose- I nduced D egradation deficient, we discover supramolecular chelate assembly as an E3 ligase strategy for targeting an oligomeric substrate. Cryo EM structures show that to bind the tetrameric substrate...

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Literature Corpus work: b21dd58a-bb44-5feb-89ca-f55166ef570c
DOI: 10.1101/2021.04.07.436316

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