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Expanding PROTACtable genome universe of E3 ligases

16 Oct 2023

Abstract excerpt

Proteolysis-targeting chimera (PROTAC) and other targeted protein degradation (TPD) molecules that induce degradation by the ubiquitin-proteasome system (UPS) offer new opportunities to engage targets that remain challenging to be inhibited by conventional small molecules. One fundamental element in the degradation process is the E3 ligase. However, less than 2% amongst hundreds of E3 ligases in the human genome...

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PMID: 37845222
DOI: 10.1038/s41467-023-42233-2

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