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GlueFinder: A Data-Driven Framework for the Rational Discovery of Molecular Glues

2025-10-17

Abstract excerpt

Molecular glues can drive targeted protein degradation by stabilizing ternary complexes between proteins of interest and E3 ubiquitin ligases, but rational design has lagged due to limited rules for interface recognition and an overreliance on a few ligases (e.g., VHL or Cereblon). We introduce GlueFinder, a systematic, unbiased platform that leverages structural bioinformatics to mine the Protein Data Bank for li...

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Identifiers and source

Literature Corpus work
f726c2a6-e3c7-5fce-8e5a-ecba36915b7e
DOI
10.1101/2025.10.17.683126
Open publication

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GlueFinder: A Data-Driven Framework for the Rational Discovery of Molecular GluesDOI 10.1101/2025.10.17.683126
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