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Article

A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.

Molecular systems biology - 1 Jan 2009

van Wijk Sjoerd J L, de Vries Sjoerd J, Kemmeren Patrick, Huang Anding, Boelens Rolf, Bonvin Alexandre M J J, Timmers H Th Marc

Abstract excerpt

Covalent attachment of ubiquitin to substrates is crucial to protein degradation, transcription regulation and cell signalling. Highly specific interactions between ubiquitin-conjugating enzymes (E2) and ubiquitin protein E3 ligases fulfil essential roles in this process. We performed a global yeast-two hybrid screen to study the specificity of interactions between catalytic domains of the 35 human E2s with 250...

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Identifiers

PMID: 19690564
DOI: 10.1038/msb.2009.55
PMCID: PMC2736652

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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