Article

Structural landscape of AAA+ ATPase motor states in the substrate-degrading human 26S proteasome reveals conformation-specific binding of TXNL1

2024-11-09

Abstract excerpt

<h4>Summary</h4> The 26S proteasome targets many cellular proteins for degradation during general homeostasis, protein quality control, and the regulation of vital processes. A broad range of proteasome-interacting cofactors thereby modulates these functions and aids in substrate degradation. Here, we solved several high-resolution structures of the redox active cofactor TXNL1 bound to the human 26S proteasome at...

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Literature Corpus work: a2d599e8-18cc-5607-b587-f12a2fcb60a6
DOI: 10.1101/2024.11.08.622731

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Structural landscape of AAA+ ATPase motor states in the substrate-degrading human 26S proteasome reveals conformation-specific binding of TXNL1DOI 10.1101/2024.11.08.622731Read

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