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Article

Exploring the topology of the Gid complex, the E3 ubiquitin ligase involved in catabolite-induced degradation of gluconeogenic enzymes.

The Journal of biological chemistry - 20 Jul 2012

Menssen Ruth, Schweiggert Jörg, Schreiner Jens, Kusevic Denis, Reuther Julia, Braun Bernhard, Wolf Dieter H

Abstract excerpt

In the yeast Saccharomyces cerevisiae, key regulatory enzymes of gluconeogenesis such as fructose-1,6-bisphosphatase are degraded via the ubiquitin proteasome system when cells are replenished with glucose. Polyubiquitination is carried out by the Gid complex, a multisubunit ubiquitin ligase that consists of seven different Gid (glucose-induced degradation-deficient) proteins. Under gluconeogenic conditions the...

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Identifiers

PMID: 22645139
DOI: 10.1074/jbc.M112.363762
PMCID: PMC3408164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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