Article
Structural basis and regulation of the reductive stress response.
Cell - 14 Oct 2021
Manford Andrew G, Mena Elijah L, Shih Karen Y, Gee Christine L, McMinimy Rachael, Martínez-González Brenda, Sherriff Rumi, Lew Brandon, Zoltek Madeline, Rodríguez-Pérez Fernando, Woldesenbet Makda, Kuriyan John, Rape Michael
Abstract excerpt
Although oxidative phosphorylation is best known for producing ATP, it also yields reactive oxygen species (ROS) as invariant byproducts. Depletion of ROS below their physiological levels, a phenomenon known as reductive stress, impedes cellular signaling and has been linked to cancer, diabetes, and cardiomyopathy. Cells alleviate reductive stress by ubiquitylating and degrading the mitochondrial gatekeeper...
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